Cirpusins® treatment resulted in a dose-dependent reduction in lipid accumulation in 3T3 L1 fibroblast cells without affecting cell viability. The reduction in adipogenesis was associated with reduced levels of
Transcripts for peroxisome proliferator-activated receptor γ (PPARγ)
Adipocyte protein 2/adipocyte fatty acid-binding protein (aP2) (Figure 1)
Figure 1: Anti-Adipogenesis Activity of Cirpusins®in vitro (A) Percentage inhibition of adipogenesis activity
(B) Fold change in the transcripts of PPARγ and aP2 genes
