Background

Cyperus rotundus is a perennial herb indigenous to Indian subcontinent. Traditionally, it has been studied for its potential to support various aspects of health, including cognitive function, healthy inflammation support, body temperature regulation, pain relief, lipid balance, healthy weight management, gastrointestinal well-being, liver health, and more (Al-Snafi AE, 2016).

The major organic chemicals isolated from various parts of the Cyperus species include quinonoid pigments, sesquiterpenoids, flavonoids and stilbene derivatives. Several monoterpenoids, amino acids and fatty acids are also reported.

Stilbenes are polyphenols with vast biological applications. They are phytoalexins, which are antimicrobial compounds produced to protect the plant from fungal infection and toxin. Many naturally occurring stilbene compounds like Resveratrol, Oxyresveratrol, Piceatannol, Pterostilbene, and their analogs have multi-functional effects. Cirpusins® a patented and clinically studied extract of dried, pulverized rhizomes of Cyperus rotundus has been reported to contain Scirpusin A, Scirpusin B, and Piceatannol as major compounds.